أبحاث منشورة للعلماء المنتسبين :

Mitochondrial-Associated Cell Death Mechanisms Are Reset To An Embryonic-Like State In Aged Donor-Derived Ips Cells Harboring Chromosomal Aberrations.
Prigione A, Hossini AM, Lichtner B, Serin A, Fauler B, Megges M, Lurz R, Lehrach H, Makrantonaki E, Zouboulis CC, Adjaye J.
PLoS One. 2011;6(11):e27352. Epub 2011 Nov 14.

Estrogen inhibits Dlk1/FA1 production: a potential mechanism for estrogen effects on bone turnover.
Abdallah BM, Bay-Jensen AC, Srinivasan B, Tabassi NC, Garnero P, Delaissé JM, Khosla S, Kassem M.
J Bone Miner Res. 2011 Oct;26(10):2548-51.

Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population.
Smith JO, Aarvold A, Tayton ER, Dunlop DG, Oreffo RO.
Tissue Eng Part B Rev. 2011 Oct;17(5):307-20. Epub 2011 Jun 30.

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.
Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J.
Stem Cells. 2011 Sep;29(9):1338-48. doi: 10.1002/stem.683.

Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.
Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Säämänen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.
J Biol Chem. 2011 Sep 16;286(37):32140-9. Epub 2011 Jul 1.

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5.
Frost M, Andersen T, Gossiel F, Hansen S, Bollerslev J, van Hul W, Eastell R, Kassem M, Brixen K.
J Bone Miner Res. 2011 Aug;26(8):1721-8.

Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.
Mah N, Wang Y, Liao MC, Prigione A, Jozefczuk J, Lichtner B, Wolfrum K, Haltmeier M, Flöttmann M, Schaefer M, Hahn A, Mrowka R, Klipp E, Andrade-Navarro MA, Adjaye J.
PLoS One. 2011;6(8):e24351. Epub 2011 Aug 31.

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency.
McMurray RJ, Gadegaard N, Tsimbouri PM, Burgess KV, McNamara LE, Tare R, Murawski K, Kingham E, Oreffo RO, Dalby MJ.
Nat Mater. 2011 Jul 17;10(8):637-44.

Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.
Aarvold A, Smith JO, Tayton ER, Tilley S, Dawson JI, Lanham SA, Briscoe A, Dunlop DG, Oreffo RO.
Regen Med. 2011 Jul;6(4):461-7.

Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation.
Jozefczuk J, Prigione A, Chavez L, Adjaye J.
Stem Cells Dev. 2011 Jul;20(7):1259-75.

Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependentendothelial interaction.
Burns JS, Kristiansen M, Kristensen LP, Larsen KH, Nielsen MO, Christiansen H, Nehlin J, Andersen JS, Kassem M.
PLoS One. 2011;6(7):e21888. Epub 2011 Jul 11.

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets.
Marie PJ, Kassem M.
Eur J Endocrinol. 2011 Jul;165(1):1-10. Epub 2011 May 4. Review.

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.
Saeed H, Abdallah BM, Ditzel N, Catala-Lehnen P, Qiu W, Amling M, Kassem M.
J Bone Miner Res. 2011 Jul;26(7):1494-505. doi: 10.1002/jbmr.349.

New factors controlling the balance between osteoblastogenesis and adipogenesis.
Abdallah BM, Kassem M.
Bone. 2011 Jul 1. [Epub ahead of print]

Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes.
Bjerre L, Bünger C, Baatrup A, Kassem M, Mygind T.
J Biomed Mater Res A. 2011 Jun 1;97(3):251-63. doi: 10.1002/jbm.a.33051. Epub 2011 Mar 25.

Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces.
Dolatshahi-Pirouz A, Jensen TH, Kolind K, Bünger C, Kassem M, Foss M, Besenbacher F.
Colloids Surf B Biointerfaces. 2011 May 1;84(1):18-25. Epub 2010 Dec 8.

A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.
Wang Y, Adjaye J.
Stem Cell Rev. 2011 Jun;7(2):331-41.

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance.
D'Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR.
Radiother Oncol. 2011 Jun;99(3):373-8. Epub 2011 Jun 29.

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.
Kassem M, Marie PJ.
Aging Cell. 2011 Apr;10(2):191-7. Review.

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo.
Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, Kassem M.
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6139-44.

Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A.
El-Serafi AT, Oreffo RO, Roach HI.
Differentiation. 2011 Jan;81(1):35-41.

siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Andersen MØ, Nygaard JV, Burns JS, Raarup MK, Nyengaard JR, Bünger C, Besenbacher F, Howard KA, Kassem M, Kjems J.
Mol Ther. 2010 Nov;18(11):2018-27.

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.
Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J.
PLoS One. 2010 Oct 29;5(10):e13703.

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage.
Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmermann B, Lehrach H, Herwig R, Adjaye J.
Genome Res. 2010 Oct;20(10):1441-50.

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency.
McMurray RJ, Gadegaard N, Tsimbouri PM, Burgess KV, McNamara LE, Tare R, Murawski K, Kingham E, Oreffo RO, Dalby MJ.
Nat Mater. 2011 Jul 17;10(8):637-44.

Impaired cell surface expression of HLA-B antigens on mesenchymal stem cells and muscle cell progenitors.
Isa A, Nehlin JO, Sabir HJ, Andersen TE, Gaster M, Kassem M, Barington T.
PLoS One. 2010 May 28;5(5):e10900.

Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity.
Larsen KH, Frederiksen CM, Burns JS, Abdallah BM, Kassem M.
J Bone Miner Res. 2010 Apr;25(4):796-808.

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin.
Frost M, Andersen TE, Yadav V, Brixen K, Karsenty G, Kassem M.
J Bone Miner Res. 2010 Mar;25(3):673-5.

The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri.
Knott ML, Matthaei KI, Foster PS, Dent LA.
Mol Immunol. 2009 Aug;46(13):2714-22.

Identification of therapeutic drug targets through genetically manipulated mice: are we getting it right?
Matthaei KI.
Pharmacol Ther. 2009 Jul;123(1):32-6.

Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses.
Phipps S, Lam CE, Kaiko GE, Foo SY, Collison A, Mattes J, Barry J, Davidson S, Oreo K, Smith L, Mansell A, Matthaei KI, Foster PS.
Am J Respir Crit Care Med. 2009 May 15;179(10):883-93. Erratum in: Am J Respir Crit Care Med. 2009 Nov 15;180(10):1032.